Publications

* correponding author; # co-first author

2023

1. J Hu, P Tan, M Ishihara, NA Bailey, S Schokrpur, J G Reynoso, Y Zhang, R J Lim, C Dumitras, L Yang, S MDubinett,  P S Jat, J Van Snick, J Huang,A I Chin, R M Prins, T G Graeber, H Xu* and L Wu*, Tumor Heterogeneity in VHL Drives Metastasis in Clear Cell Renal CellCarcinoma, Signal Transduction and Targeted Therapy, 2023, 8, (1), 155
2. J Hu*, D J Smithand L Wu*, VHL L169P Variant Does Not Alter Cellular Hypoxia Tension in ClearCell Renal Cell Carcinoma. Int. J. Mol. Sci., 2023, 24,(18), 14075.
3. K Flora, M Ishihara, Z Zhang, E S.Bowen, A Wu, T Ayoub, J Huang, C Cano-Ruiz, M Jackson, K Reghu, Y Ayoub, YZ Zhu, HR Tseng, ZH Hong, J Hu* and L Wu*. Exosomesfrom Von Hippel-Lindau-Null Cancer Cells Promote Metastasis in Renal CellCarcinoma. Int. J. Mol. Sci.. 2023, 24(24), 17307.
4. N Sun,C Zhang, YT Lee, BV Tran, J Wang, H Kim, J Lee, RY Zhang, JJ Wang, J Hu,Z Zhang, MS Alsudaney, KC Hou, H Tang, TX Zhang, IY Liang, Z Zhou, M Chen, AHYeh, W Li, XJ Zhou, HR Chang, SB Han, S Sadeghi, RS Finn, S Saab, RW Busuttil, MNoureddin, WS Ayoub, A Kuo, V Sundaram, B Al-Ghaieb, J Palomique, K Kosari, IKKim, T Todo, NN Nissen, ML Tomasi, S You, EM Posadas, JX Wu, M Wadehra, MS Sim,Y Li, HL Wang, SW French, SC Lu, L Wu, R Pei, L Liang, JD Yang, VG Agopian, HR Tseng,Y Zhu. HCC EV ECG score: An extracellular vesicle-based protein assay fordetection of early-stage hepatocellular carcinoma. Hepatology. 2023 Mar 1;77(3):774-788.

2022

1.  Z Zhang, J Hu, M Ishihara, AC Sharrow, K Flora, Y He, L Wu, The miRNA-21-5p Payload in Exosomes from M2 Macrophages Drives Tumor Cell Aggression via PTEN/Akt Signaling in Renal Cell Carcinoma. Int. J. Mol. Sci. 2022, 23, 3005. 

2021

1. Z Zhang., G Ai, L Chen, S Liu, G Chen, X Zhu, C Zhang, H Qin, J Hu*, J Huang*, Associations of immunological features with COVID-19 severity: a systematic review and meta-analysis. BMC Infect Dis 21, 738 (2021).
2. W Guan, F Li, Z Zhao,Z Zhang, J Hu, Y Zhang. Tumor-Associated Macrophage Promotes theSurvival of Cancer Cells upon Docetaxel Chemotherapy via theCSF1/CSF1R–CXCL12/CXCR4 Axis in Castration-Resistant Prostate Cancer. Genes.2021;12(5):773
3.  M Gao#, H Wu#, R Plamthottam, Z Xie, Y Liu, J Hu, S Wu, L Wu, X He and Q Pei, Skin Temperature Triggered, Debonding-on-Demand Sticker for a Self-Powered Mechanosensitive Communication System, Matter, 2021
4.  J Zeng, H Xu, C Huang, Y Sun, H Xiao, G Yu, H Zhou, Y Zhang, W Yao, W Xiao, J Hu, Lily Wu, J Xing, T Wang, Z Chen, Z Ye and K Chen, CD46 splice variant enhances translation of specific mRNAs linked to an aggressive tumor cell phenotype in bladder cancer. Mol Ther Nucleic Acids. 2021 Feb 24;24:140-153.
5.  K Chen, J Zeng, Y Sun, W Ouyang, G Yu, H Zhou, Y Zhang, W Yao, W Xiao, J Hu, J Xing, K Xiao, L Wu, Z Chen, Z Ye and H Xu, Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma. Cancer Commun. 2021; 41: 316–332

2020

1.  M Ishihara#, J Hu#, X Zhang, Y Choi, A Wong, C Cano-Ruiz,     R Zhao, P Tan, J Tso, L Wu, Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane, Journal of Visualized Experiments, 2020(156):e60314.
2.  AC Sharrow, M. Ishihara, J. Hu, IH Kim, and L Wu. Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers. Journal of Visualized Experiments, 2020(155):e60651.
3..  J Dong, RY Zhang, N Sun, J Hu, MD Smalley, A Zhou, Y Hua, W Rothermich, M Chen, J Chen, J Ye, P Teng, D Qi, JA Toretsky, JS Tomlinson, M Li, PS Weiss, SJ Jonas, N Federman, L Wu, M Zhao, HR Tseng, Y Zhu, Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies. Advanced Functional Materials.2020 Sep 13: 2003237

2019

1.  J Hu, W. Guan, L. Yan, Z. Ye, L. Wu, H. Xu, Cancer Stem Cell Marker Endoglin (CD105) Induces Epithelial Mesenchymal Transition (EMT) but Not Metastasis in Clear Cell Renal Cell Carcinoma. Stem Cells International, 2019: 9.
2.  J Hu, M. Ishihara, A. I. Chin, L. Wu, Establishment of xenografts of urological cancers on chicken chorioallantoic membrane (CAM) to study metastasis. Precis Clin Med, 2019;2(3):140-51.
3.  W Guan#, J Hu#, L. Yang, P. Tan, Z. Tang, B. West, G. Bollag, H. Xu, and L. Wu, Inhibition of TAMs improves the response to docetaxel in castration-resistant prostate cancer. Endocrine Related Cancer, 2019. 26(1): p. 131-140.
4.  L Yan, B Ding, H Liu, Y Zhang, J Zeng, J Hu, W Yao, G Yu, R An, Z Chen, Z Ye, J Xing, K Xiao, L Wu, H Xu, Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma. Theranostics. 2019;9(26):8377-8391. 2019 Oct 22.
5. H Zhou, K Tang, H Liu,J Zeng, H Li, L Yan, J Hu, W Guan, K Chen, H Xu, Z Ye, Regulatory Network of Two Tumor-Suppressive Noncoding RNAs Interferes with the Growth andMetastasis of Renal Cell Carcinoma. Molecular Therapy - Nucleic Acids.2019; 16:554-65

2018

1.  J Hu., S. Schokrpur, M. Archang, K. Hermann, A. C. Sharrow, P. Khanna, J. Novak, S Signoretti, R.S. Bhatt, B.S. Knudsen, H. Xu, and L. Wu, A Non-integrating Lentiviral Approach Overcomes Cas9-Induced Immune Rejection to Establish an Immunocompetent Metastatic Renal Cancer Model. Molecular Therapy - Methods & Clinical Development, 9: 203, 2018

2017

1. J Hu, W Guan, P Liu, J Dai, K. Tang, H. Xiao, Y. Qian, A. C.Sharrow, Z. Ye, L. Wu, and H. Xu, Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in RenalCancer Stem Cells. Stem Cell Reports, 2017. 9(2): p. 464-477
2. K Chen, J. Zeng, G. Yu, H. Zhou, C.Huang, W. Yao, W. Xiao, J Hu, W.Guan, L. Wu, J. Huang, Q. Huang, H. Xu and Z. Ye, Alternative splicing of EZH2 pre-mRNA by SF3B3 contributes to thetumorigenic potential of renal cancer. Clinical Cancer Research, 2017 Jul 1;23(13):3428-3441.
3. T Yang,H. Zhou, P. Liu, L. Yan, W. Yao, K. Chen, J. Zeng, H. Li, J Hu, X. Hua, Z. Ye, lncRNAPVT1 and its splicing variant function as competing endogenous RNA to regulateclear cell renal cell carcinoma progression. Oncotarget, 2017.8(49): p. 85353-85367.1.

2016

1. S Schokrpur,J Hu, D.L. Moughon, P. Liu, L.C.Lin, K. Hermann, S. Mangul, W. Guan, M. Pellegrini, and H. Xu, CRISPR-Mediated VHL Knockout Generates anImproved Model for Metastatic Renal Cell Carcinoma. Scientific Reports,2016. 6.
2. K Chen, J. Zeng, K. Tang, H. Xiao, J Hu, C. Huang, W. Yao, G. Yu, W. Xiao,and W. Guan, miR‐490‐5p suppresses tumour growth in renalcell carcinoma through targeting PIK3CA. Biologyof the Cell, 2016. 108(2): p. 41-50.
3. K Chen, J. Zeng, H. Xiao, C. Huang, J Hu, W. Yao, G. Yu, W. Xiao, H. Xu,and Z. Ye, Regulation of glucosemetabolism by p62/SQSTM1 through HIF1α. J Cell Sci, 2016. 129(4): p.817-830.

2015

1. H Xiao, K Tang, P Liu, K Chen, J Hu, J Zeng, W Xiao, G Yu, W Yao, H Zhou,H Li, Y Pan, A Li, Z Ye, J Wang, H Xu, Q Huang. LncRNA MALAT1 functions as acompeting endogenous RNA to regulate ZEB2 expression by sponging miR-200s inclear cell kidney carcinoma. Oncotarget. 2015 Nov 10;6(35):38005-15.
2. H Xiao., J. Zeng, H. Li, K. Chen, G. Yu,J Hu, K. Tang, H. Zhou, Q. Huang,and A. Li, MiR-1 downregulationcorrelates with poor survival in clear cell renal cell carcinoma where itinterferes with cell cycle regulation and metastasis. Oncotarget, 2015. 6(15): p. 13201-13215.

2014

1. H Xiao,H. Li, G. Yu, W. Xiao, J Hu, K.Tang, J. Zeng, W. He, G. Zeng, and Z. Ye, MicroRNA-10bpromotes migration and invasion through KLF4 and HOXD10 in human bladder cancer. Oncology reports, 2014. 31(4): p. 1832-1838.
2. C Wang, Z. Chen, Q. Ge, J Hu, F. Li, J. Hu, H. Xu, Z. Ye, and L.-C. Li, Up‐regulation ofp21WAF1/CIP1 by miRNAs and its implications in bladder cancer cells. FEBS Letters,2014. 588(24): p. 4654-4664.
3. G Yu, H. Li, J. Wang, K. Gumireddy, A.Li, W. Yao, K. Tang, W. Xiao, J. Hu,and H. Xiao, miRNA-34a suppresses cellproliferation and metastasis by targeting CD44 in human renal carcinoma cells. Journal of Urology, 2014. 192(4):p. 1229-1237.